Detective Isaac Bell thwarts the attempted assassination of a United States Senator shortly after meeting the man. This heroic rescue is just the start of the mystery for Bell who suspects that the would-be assassins have a more dangerous agenda - one involving the nearly constructed Panama Canal. While the Senator supports the building of the canal there are many including a local Panamanian insurgency known as the Red Vipers who never want to see its completion. With millions of dollars and the fates of two nations at stake Bell heads to Panama to find answers. After a deadly bombing at the Canal's construction site he is determined to stop the insurgents before they can attack again.

Part of the The Isaac Bell Series series.